The Metabolomics Sub-Study

Metabolomics Sub-Study Overview

Recruitment to the main By-Band-Sleeve Study was completed in September 2019. In April 2022 recruitment closed to the By-Band-Sleeve sub-study – the Metabolomics study, participants in the sub-study will be followed up to one year post surgery.  The aim of this sub-study is to find out how the body responds to weight loss following bariatric surgery. The study involves donating a small sample of blood before surgery and again one year later. These samples will be used to look for small molecules whose levels change with weight loss.

Which hospitals are taking part?

The By-Band-Sleeve Metabolomics sub-study recruited at these hospitals: University Hospital Southampton; Musgrove Park Hospital, Somerset NHS Foundation Trust, Taunton; Royal Cornwall Hospital, Truro; Heartlands Hospital, Birmingham; Queen Alexandra Hospital, Portsmouth; Homerton Hospital, London; Southmead Hospital, North Bristol Trust.

How do I take part?

Adults who were referred for bariatric surgery (gastric band surgery, gastric bypass surgery or sleeve gastrectomy surgery) at any of the above hospitals and met the eligibility criteria for the study were able to  take part. Patients were eligible regardless of the type of surgery they were planning to have. Patients were given some information to read about the study and the chance to discuss it with the health professionals on the team. If patients decided to take part in the study, their operation took place in the same way that it would normally. All participants will be followed up by the study team one year after their surgery.

Metabolomics Study Team

The study is led by Professor Nic Timpson and coordinated by Dr Laura Corbin, both of whom are based in the Bristol Medical School, University of Bristol. They are supported by the main By-Band-Sleeve study team from the Bristol Trials Centre at the University of Bristol. The Metabolomics Study started in September 2019 and will end when the final patient has completed follow up and all data has been analysed. The study is funded by the Wellcome Trust (ref: 202802/Z/16/Z).